Positive regulation of transcription by RNA polymerase III

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription by RNA polymerase III pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR89, GMPPB, and PPP4R3A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription by RNA polymerase III activity versus WDR89 in UCEC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR89 →	+0.200	+0.042	<.001	.005	3	6
LUAD	GMPPB →	-0.161	-0.023	.001	.005	3	6
LUAD	PPP4R3A →	+0.226	+0.043	<.001	<.001	3	6
CCRCC	PARP4 →	-0.337	-0.038	<.001	<.001	3	6
LSCC	RAE1 →	+0.122	+0.028	.005	.001	3	6
LSCC	AP3M1 →	-0.105	-0.029	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045945 vs WDR89 — UCEC

Explore this scatter interactively →