Positive regulation of transcription by RNA polymerase III

Across TCGA cell cohorts, RNA activity of the Positive regulation of transcription by RNA polymerase III pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB1A, GLI3, and KLF11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription by RNA polymerase III activity versus RAB1A in LUNG_NSCLC_LUSC (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAB1A →	-0.674	-0.265	.003	.005	3	5
URINARY_TRACT	GLI3 →	+0.991	+0.214	.006	.001	3	4
URINARY_TRACT	KLF11 →	+1.559	+0.212	<.001	.001	3	4
BLOOD_Leukemia	SIL1 →	-0.874	-0.245	.006	.001	3	4
LIVER	ATP7B →	-2.013	-0.589	.003	.001	3	4
BLOOD_Leukemia	TTC7B →	-2.018	-0.228	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045945 vs RAB1A — LUNG_NSCLC_LUSC

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