Positive regulation of transcription by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription by RNA polymerase I pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHD4, SMC1A, and CPSF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription by RNA polymerase I activity versus CHD4 in UCEC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHD4 →	+0.217	+0.070	.002	<.001	3	7
LSCC	SMC1A →	+0.230	+0.057	.001	<.001	3	7
LSCC	CPSF1 →	+0.232	+0.068	<.001	<.001	3	7
LSCC	THOC6 →	+0.317	+0.069	<.001	<.001	3	7
LSCC	DDX27 →	+0.383	+0.054	<.001	<.001	3	7
LUAD	REXO4 →	+0.417	+0.041	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045943 vs CHD4 — UCEC

Explore this scatter interactively →