Positive regulation of transcription by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCI, PTH1R, and LMOD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription by RNA polymerase I activity versus FANCI in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FANCI →	+0.953	+0.535	<.001	<.001	3	8
OV	PTH1R →	-0.931	-0.280	.001	.001	3	8
BRCA	LMOD1 →	-1.121	-0.291	<.001	<.001	3	8
UCEC	ZCCHC24 →	-0.922	-0.313	<.001	<.001	3	8
GBM	TMEM119 →	-1.002	-0.374	<.001	<.001	3	8
BRCA	GPIHBP1 →	-1.235	-0.326	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045943 vs FANCI — GBM

Explore this scatter interactively →