Positive regulation of transcription by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Positive regulation of transcription by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC159, RPS27L, and DNAJC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription by RNA polymerase I activity versus CCDC159 in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC159 →	-1.244	-0.163	<.001	<.001	3	6
OESOPHAGUS	RPS27L →	-1.090	-0.199	.003	.009	3	6
LUNG_SCLC	DNAJC3 →	-1.211	-0.155	.001	.001	3	6
SKIN	AGPAT3 →	-0.659	-0.252	<.001	<.001	3	6
LUNG_NSCLC_LUAD	SPPL2A →	-0.900	-0.304	<.001	<.001	3	6
BLOOD_Leukemia	MAFG →	-0.918	-0.186	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045943 vs CCDC159 — BLOOD_Leukemia

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