Positive regulation of steroid metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of steroid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP2, GGT5, and THBS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of steroid metabolic process activity versus LTBP2 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LTBP2 →	+0.951	+0.180	<.001	<.001	3	5
LSCC	GGT5 →	+0.804	+0.651	<.001	<.001	3	5
GBM	THBS1 →	+1.140	+0.158	.004	<.001	3	5
GBM	FOLR2 →	+1.004	+0.196	.001	<.001	3	5
GBM	C5AR1 →	+0.803	+0.147	.002	.001	3	5
LSCC	H2AC20 →	-0.690	-0.692	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045940 vs LTBP2 — GBM

Explore this scatter interactively →