Positive regulation of steroid metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of steroid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAIAP2L1, RPA4, and ZNF165, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAIAP2L1 grouped by Positive regulation of steroid metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BAIAP2L1 →	-0.135	-0.089	.003	.001	3	4
BLOOD_Lymphoma	RPA4 →	+0.375	+0.123	<.001	.002	3	4
BREAST	ZNF165 →	-0.127	-0.075	.003	<.001	3	4
LARGE_INTESTINE	SEC13 →	-0.320	-0.158	.008	.001	3	4
LUNG_NSCLC_LUSC	LYNX1 →	+0.210	+0.112	<.001	.002	3	4
BREAST	CDC14B →	+0.214	+0.089	.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAIAP2L1 by Positive regulation of steroid metabolic process activity — BREAST

Explore this box plot interactively →