Negative regulation of steroid metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of steroid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A10, COQ10B, and RPRD1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC16A10 grouped by Negative regulation of steroid metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC16A10 →	+1.253	+0.997	.001	.009	3	4
LUNG_SCLC	COQ10B →	+1.108	+0.323	<.001	<.001	3	4
LUNG_NSCLC_LUSC	RPRD1B →	+0.676	+0.221	.003	<.001	3	4
OVARY	INTS6L →	-1.329	-0.687	.002	.004	3	4
SOFT_TISSUE	ST3GAL4 →	+1.292	+1.160	.001	.005	3	4
URINARY_TRACT	RAB22A →	+0.876	+1.810	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC16A10 by Negative regulation of steroid metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →