Positive regulation of muscle contraction

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPHK1, RGS2, and PTGS2, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle contraction activity versus SPHK1 in CHOL (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	SPHK1 →	+2.267	+0.047	.003	.001	2	21
LAML	RGS2 →	+1.509	+0.044	<.001	<.001	3	18
PAAD	PTGS2 →	+1.506	+0.032	<.001	<.001	3	18
CHOL	INHBA →	+1.786	+0.047	.003	<.001	3	17
DLBC	TREM1 →	+1.624	+0.027	<.001	.005	2	18
BLCA	ITPRIP →	+0.739	+0.031	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045933 vs SPHK1 — CHOL

Explore this scatter interactively →