Positive regulation of muscle contraction

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTTN, RND3, and ATIC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle contraction activity versus CTTN in HNSC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CTTN →	+1.472	+0.165	<.001	<.001	3	4
BRCA	RND3 →	+0.552	+0.095	.008	.007	3	4
CCRCC	ATIC →	-0.557	-0.099	.001	.008	3	4
LUAD	TMEM59 →	+0.329	+0.086	<.001	.004	3	4
LUAD	NAT8L →	-0.380	-0.132	.009	<.001	3	4
CCRCC	RPTOR →	-0.363	-0.123	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045933 vs CTTN — HNSC

Explore this scatter interactively →