Positive regulation of muscle contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PELP1, NECTIN3, and MRPL15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PELP1 grouped by Positive regulation of muscle contraction-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PELP1 →	+0.712	+0.937	.004	.002	3	4
OVARY	NECTIN3 →	-1.300	-0.928	<.001	.001	3	4
KIDNEY	MRPL15 →	+0.659	+0.947	.003	.001	3	4
BREAST	ATXN10 →	+0.670	+0.794	.002	.001	3	4
LARGE_INTESTINE	IL32 →	-3.273	-0.677	.001	.006	2	4
UPPER_AERODIGESTIVE_TRACT	SMYD4 →	+1.280	+0.220	<.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PELP1 by Positive regulation of muscle contraction activity — STOMACH

Explore this box plot interactively →