Positive regulation of muscle contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTO1, BCAM, and NRP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle contraction activity versus GSTO1 in BLOOD_Leukemia (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSTO1 →	+0.449	+0.114	.006	.007	1	10
PANCREAS	BCAM →	-1.932	-0.299	<.001	.001	3	5
LUNG_NSCLC_LUAD	NRP1 →	+2.590	+0.201	<.001	.001	3	5
SKIN	ZNF330 →	+0.953	+0.183	<.001	.001	3	5
LUNG_NSCLC_LUAD	WASHC2C →	+0.597	+0.170	<.001	<.001	3	5
SKIN	WASHC2A →	+0.637	+0.228	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045933 vs GSTO1 — BLOOD_Leukemia

Explore this scatter interactively →