Negative regulation of muscle contraction

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS2, ARHGAP42, and PTGS2, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle contraction activity versus RGS2 in CHOL (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	RGS2 →	+2.319	+0.055	<.001	<.001	3	29
THYM	ARHGAP42 →	+1.522	+0.044	<.001	<.001	3	27
UCS	PTGS2 →	+2.075	+0.044	<.001	.003	2	28
CHOL	TNFAIP3 →	+1.373	+0.043	.004	.006	2	27
CHOL	OSMR →	+1.729	+0.042	.003	.003	2	27
THYM	CRIM1 →	+1.919	+0.050	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045932 vs RGS2 — CHOL

Explore this scatter interactively →