Negative regulation of muscle contraction

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM2_S2123, TBC1D2B, and WDR43, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle contraction activity versus SRRM2_S2123 in GBM (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRRM2_S2123 →	-0.298	-0.109	<.001	<.001	3	9
GBM	TBC1D2B →	+0.389	+0.107	<.001	<.001	3	9
LSCC	WDR43 →	-0.320	-0.082	<.001	<.001	3	9
BRCA	C17orf75 →	-0.405	-0.047	<.001	.001	3	9
LSCC	CLIC2 →	+0.467	+0.091	<.001	<.001	3	9
LSCC	CEBPZ →	-0.418	-0.082	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045932 vs SRRM2_S2123 — GBM

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