Negative regulation of muscle contraction

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF598, STK24, and OPN1SW, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle contraction activity versus ZNF598 in BLOOD_Lymphoma (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF598 →	+0.632	+0.245	<.001	<.001	3	4
LIVER	STK24 →	-1.125	-0.279	.001	<.001	3	3
LIVER	OPN1SW →	+0.346	+0.262	.008	.009	3	3
LIVER	TNFRSF25 →	-1.600	-0.251	.007	.005	3	3
SKIN	PKMYT1 →	+0.689	+0.225	<.001	<.001	3	3
BLOOD_Myeloma	IL15RA →	-1.154	-0.235	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045932 vs ZNF598 — BLOOD_Lymphoma

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