Positive regulation of mitotic cell cycle

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTBP, ORC6, and CDC6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic cell cycle activity versus MTBP in LUAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTBP →	+0.874	+0.151	<.001	<.001	3	6
UCEC	ORC6 →	+1.023	+0.224	.001	.002	3	6
UCEC	CDC6 →	+1.480	+0.280	.008	<.001	3	6
LSCC	FANCI →	+1.319	+0.209	.003	.004	3	6
LSCC	TICRR →	+1.436	+0.246	.007	<.001	3	6
LSCC	E2F7 →	+1.126	+0.186	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045931 vs MTBP — LUAD

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