Positive regulation of mitotic cell cycle

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG9B, SAMD9, and C1QBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATG9B grouped by Positive regulation of mitotic cell cycle-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ATG9B →	+1.361	+0.192	.001	.002	3	5
URINARY_TRACT	SAMD9 →	+2.721	+0.184	<.001	<.001	3	4
LARGE_INTESTINE	C1QBP →	-0.620	-0.162	.002	<.001	3	4
LARGE_INTESTINE	PPDPF →	+0.747	+0.162	.001	<.001	3	4
BREAST	WFS1 →	+1.081	+0.115	.004	.004	3	4
STOMACH	NPM3 →	-0.955	-0.128	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATG9B by Positive regulation of mitotic cell cycle activity — SOFT_TISSUE

Explore this box plot interactively →