Positive regulation of mitotic cell cycle

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SF3A2, CFB, and ELAVL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic cell cycle activity versus SF3A2 in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SF3A2 →	+0.589	+1.011	<.001	<.001	3	6
BLOOD_Lymphoma	CFB →	-1.237	-0.108	.005	.008	3	5
LIVER	ELAVL1 →	+0.724	+1.236	<.001	<.001	3	5
STOMACH	SRSF3 →	+0.839	+1.087	.003	.005	3	4
STOMACH	BRF1 →	+0.929	+1.296	.004	<.001	3	4
LARGE_INTESTINE	STMN1 →	+1.188	+1.188	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045931 vs SF3A2 — BREAST

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