Negative regulation of mitotic cell cycle

Across TCGA cell cohorts, RNA activity of the Negative regulation of mitotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35A3, SCLY, and HPGD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mitotic cell cycle activity versus SLC35A3 in LUNG_NSCLC_LUAD (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC35A3 →	+0.852	+0.726	.003	.004	3	4
LARGE_INTESTINE	SCLY →	-0.645	-0.459	<.001	.007	3	4
PANCREAS	HPGD →	+3.346	+0.170	.003	.002	3	3
PANCREAS	METTL3 →	-0.660	-0.115	<.001	.005	3	3
PANCREAS	ZCWPW2 →	+0.243	+0.149	.001	<.001	3	3
LARGE_INTESTINE	RFK →	-0.796	-0.482	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045930 vs SLC35A3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →