Positive regulation of growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of growth pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD2, ZNF223, and HDAC7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FZD2 grouped by Positive regulation of growth-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FZD2 →	+2.708	+0.175	<.001	.001	3	5
BONE	ZNF223 →	+1.308	+0.294	.009	.002	3	5
SKIN	HDAC7 →	+0.777	+0.129	.003	.008	3	5
SKIN	MYL6 →	+0.677	+0.123	.005	.009	3	5
LIVER	COMMD5 →	+0.671	+0.172	.007	.003	3	4
UPPER_AERODIGESTIVE_TRACT	MYZAP →	+1.079	+0.139	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FZD2 by Positive regulation of growth activity — STOMACH

Explore this box plot interactively →