Regulation of female receptivity

Across TCGA patient cohorts, RNA activity of the Regulation of female receptivity pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R1B, DHX57, and TRMT61B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of female receptivity activity versus PPP1R1B in LUAD (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PPP1R1B →	+2.011	+0.413	<.001	<.001	3	5
LSCC	DHX57 →	+0.404	+0.331	<.001	.001	3	4
LSCC	TRMT61B →	+0.461	+0.380	<.001	.006	3	4
OV	NCOA1 →	+0.562	+0.539	.003	.009	2	5
COAD	STH →	+0.079	+0.818	.008	<.001	3	4
GBM	LGALS1 →	-0.570	-0.465	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045924 vs PPP1R1B — LUAD

Explore this scatter interactively →