Regulation of female receptivity

Across TCGA cell cohorts, RNA activity of the Regulation of female receptivity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCOA1, KIDINS220, and SPAST, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of female receptivity activity versus NCOA1 in BLOOD_Lymphoma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NCOA1 →	+1.750	+0.630	<.001	<.001	3	20
STOMACH	KIDINS220 →	+1.265	+1.000	<.001	.004	2	17
LUNG_NSCLC_LUSC	SPAST →	+1.068	+1.243	<.001	<.001	3	14
LUNG_NSCLC_LUSC	UBXN2A →	+0.890	+1.509	.005	<.001	3	13
STOMACH	ITSN2 →	+1.227	+1.118	<.001	.003	3	13
STOMACH	STRN →	+0.952	+1.304	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045924 vs NCOA1 — BLOOD_Lymphoma

Explore this scatter interactively →