Negative regulation of fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIBF1, APOC1, and WNK4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid metabolic process activity versus PIBF1 in URINARY_TRACT (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PIBF1 →	+0.769	+0.094	.007	.005	3	9
BLOOD_Leukemia	APOC1 →	+3.695	+0.070	<.001	<.001	3	8
LARGE_INTESTINE	WNK4 →	+1.028	+0.067	.004	<.001	3	7
URINARY_TRACT	CEBPG →	+1.001	+0.099	<.001	<.001	3	7
BLOOD_Leukemia	MTHFD2 →	+0.649	+0.060	.001	.001	3	7
BLOOD_Leukemia	APOL3 →	-1.235	-0.042	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045922 vs PIBF1 — URINARY_TRACT

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