Negative regulation of fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNS, STRBP, and HOXA10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid metabolic process activity versus GNS in BLOOD_Lymphoma (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GNS →	+1.030	+1.167	.007	.005	3	5
STOMACH	STRBP →	-0.993	-0.463	.001	.002	2	5
SKIN	HOXA10 →	-1.870	-0.257	.006	.001	3	4
BREAST	SLC15A2 →	-0.878	-0.464	.002	.004	2	5
KIDNEY	EVA1A →	+1.686	+0.256	.009	.005	3	4
BLOOD_Myeloma	BEND3 →	-0.800	-1.275	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045922 vs GNS — BLOOD_Lymphoma

Explore this scatter interactively →