Positive regulation of exocytosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIK3AP1, PLCB2, and WDR44, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of exocytosis activity versus PIK3AP1 in UCEC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIK3AP1 →	+0.537	+0.052	<.001	.002	3	6
LSCC	PLCB2 →	+0.502	+0.063	<.001	<.001	3	6
GBM	WDR44 →	+0.200	+0.053	<.001	<.001	3	6
UCEC	SRSF11_S464 →	-0.262	-0.045	.006	.005	3	5
LSCC	TEX10 →	-0.310	-0.046	<.001	<.001	3	5
UCEC	TYMP →	+0.590	+0.050	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045921 vs PIK3AP1 — UCEC

Explore this scatter interactively →