Positive regulation of exocytosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF11, TIMM50, and CXCR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of exocytosis activity versus TAF11 in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TAF11 →	-0.209	-0.306	.004	.003	3	6
BRCA	TIMM50 →	-0.538	-0.481	<.001	.001	3	5
PDAC	CXCR2 →	+1.043	+0.145	<.001	.001	3	5
LSCC	CXCR1 →	+1.071	+0.148	<.001	<.001	3	5
BRCA	BABAM1 →	-0.332	-0.332	.001	.001	3	5
UCEC	SNRPC →	-0.949	-0.392	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045921 vs TAF11 — BRCA

Explore this scatter interactively →