Positive regulation of exocytosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BUB3, PHF5A, and SAP18, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of exocytosis activity versus BUB3 in GBM (Pearson r = -0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BUB3 →	-0.352	-0.233	<.001	<.001	3	7
GBM	PHF5A →	-0.496	-0.266	<.001	<.001	3	7
GBM	SAP18 →	-0.453	-0.254	<.001	<.001	3	6
GBM	SF3A3 →	-0.268	-0.224	<.001	<.001	3	6
BRCA	SNW1 →	-0.269	-0.681	<.001	<.001	3	6
BRCA	PRPF4 →	-0.325	-0.641	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045921 vs BUB3 — GBM

Explore this scatter interactively →