Positive regulation of exocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of exocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSG101, HEATR4, and OR5L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSG101 grouped by Positive regulation of exocytosis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TSG101 →	-0.277	-0.315	<.001	.007	3	5
LUNG_SCLC	HEATR4 →	-0.185	-0.300	.009	.001	3	3
LUNG_SCLC	OR5L2 →	-0.210	-0.213	.006	.001	3	3
CNS	CHTF18 →	+0.149	+0.518	.005	.004	3	3
CNS	GMIP →	+0.130	+0.601	.002	.004	3	3
STOMACH	CCDC34 →	-0.201	-0.277	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSG101 by Positive regulation of exocytosis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →