Negative regulation of exocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVI2B_S268, FNBP1, and FYB1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of exocytosis activity versus EVI2B_S268 in LSCC (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EVI2B_S268 →	+1.053	+0.080	<.001	<.001	3	10
HNSC	FNBP1 →	+0.558	+0.074	<.001	<.001	3	10
GBM	FYB1 →	+0.676	+0.046	<.001	<.001	3	10
HNSC	GBP4 →	+0.725	+0.066	<.001	<.001	3	10
HNSC	HCLS1 →	+0.669	+0.073	<.001	<.001	3	10
HNSC	IL16 →	+0.743	+0.082	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045920 vs EVI2B_S268 — LSCC

Explore this scatter interactively →