Negative regulation of exocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18A, FANCB, and PRIM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of exocytosis activity versus KIF18A in LSCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KIF18A →	-0.426	-0.280	.005	.002	3	4
CCRCC	FANCB →	-0.316	-0.268	.001	.002	3	4
CCRCC	PRIM1 →	-0.266	-0.235	.009	.002	3	4
LSCC	KIF20A →	-0.658	-0.297	.001	.006	3	3
GBM	CENPL →	-0.484	-0.186	.002	.007	3	3
LSCC	C1orf131 →	-0.375	-0.297	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045920 vs KIF18A — LSCC

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