Negative regulation of exocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, LETM2, and GNAI2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of exocytosis activity versus ANXA1 in BLOOD_Lymphoma (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ANXA1 →	+5.882	+0.301	<.001	<.001	2	9
STOMACH	LETM2 →	+2.227	+0.212	<.001	<.001	3	8
LUNG_NSCLC_LUAD	GNAI2 →	+1.318	+0.209	<.001	<.001	3	8
STOMACH	IDS →	+1.926	+0.207	.008	.008	3	7
SOFT_TISSUE	FRMD6 →	+3.983	+0.318	<.001	.003	3	7
BLOOD_Lymphoma	ITGA3 →	+2.735	+0.237	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045920 vs ANXA1 — BLOOD_Lymphoma

Explore this scatter interactively →