Positive regulation of complement activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of complement activation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK10, APOBR, and PARVG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of complement activation activity versus DOCK10 in OV (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOCK10 →	+0.471	+0.161	<.001	<.001	3	8
UCEC	APOBR →	+0.476	+0.095	<.001	<.001	3	8
GBM	PARVG →	+0.569	+0.096	.001	<.001	3	8
GBM	SKAP2 →	+0.698	+0.113	<.001	<.001	3	8
PDAC	DOCK4 →	+0.282	+0.068	.005	.002	3	8
GBM	FMNL1 →	+0.625	+0.116	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045917 vs DOCK10 — OV

Explore this scatter interactively →