Positive regulation of complement activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of complement activation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP36, TCTEX1D4, and SHISA5P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of complement activation activity versus ZFP36 in HNSC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZFP36 →	+0.750	+0.675	.003	.002	3	3
HNSC	TCTEX1D4 →	+0.727	+0.884	<.001	<.001	3	3
HNSC	SHISA5P2 →	+0.700	+0.596	.003	.001	3	3
HNSC	RNA5SP449 →	+0.975	+0.525	<.001	.006	3	3
GBM	CEACAM4 →	+0.811	+0.870	<.001	<.001	3	3
GBM	RNF144B →	+0.826	+0.709	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045917 vs ZFP36 — HNSC

Explore this scatter interactively →