Positive regulation of complement activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of complement activation pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF571, IER3, and TRIM24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF571 grouped by Positive regulation of complement activation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZNF571 →	+0.218	+0.359	<.001	<.001	3	5
BLOOD_Lymphoma	IER3 →	+0.515	+0.155	<.001	.005	3	4
BLOOD_Lymphoma	TRIM24 →	+0.352	+0.172	<.001	.002	3	4
LARGE_INTESTINE	TBC1D3P2 →	-0.111	-0.928	.008	.001	3	4
OVARY	EYS →	+0.210	+1.377	.002	.002	3	4
CNS	COPS4 →	+0.550	+1.317	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF571 by Positive regulation of complement activation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →