Positive regulation of carbohydrate metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of carbohydrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCHL1, ZSCAN2, and COBL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of carbohydrate metabolic process activity versus UCHL1 in BLOOD_Myeloma (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	UCHL1 →	+8.142	+1.536	<.001	<.001	3	7
SKIN	ZSCAN2 →	-0.787	-0.950	.005	<.001	3	4
BREAST	COBL →	-1.553	-0.842	.007	.003	2	5
BREAST	AGR2 →	-3.882	-1.081	.005	<.001	3	4
BREAST	FHL1 →	+2.620	+1.116	<.001	<.001	2	5
BREAST	MAGIX →	-1.537	-1.178	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045913 vs UCHL1 — BLOOD_Myeloma

Explore this scatter interactively →