Positive regulation of DNA recombination

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA recombination pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAE1, ADNP, and MSH6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA recombination activity versus SAE1 in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAE1 →	+0.249	+0.063	<.001	<.001	3	6
HNSC	ADNP →	+0.226	+0.052	<.001	<.001	3	6
HNSC	MSH6 →	+0.486	+0.071	<.001	<.001	3	6
LUAD	EED →	+0.186	+0.036	.005	<.001	3	6
HNSC	S100A14 →	-0.904	-0.052	<.001	<.001	3	5
LSCC	STIM1 →	-0.455	-0.042	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045911 vs SAE1 — HNSC

Explore this scatter interactively →