Negative regulation of DNA recombination

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA recombination pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIP12, ARIH1, and EPB41L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIP12 grouped by Negative regulation of DNA recombination-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TRIP12 →	-0.211	-0.647	<.001	<.001	3	4
CNS	ARIH1 →	-0.202	-0.513	.002	.003	3	4
KIDNEY	EPB41L1 →	-0.167	-1.150	<.001	.001	3	4
LIVER	SLX4 →	-0.282	-1.260	.002	.008	3	3
LARGE_INTESTINE	CES5AP1 →	-0.186	-0.666	<.001	.006	3	3
SKIN	NTM →	-0.101	-0.542	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIP12 by Negative regulation of DNA recombination activity — CNS

Explore this box plot interactively →