Negative regulation of vasoconstriction

Across TCGA cell cohorts, RNA activity of the Negative regulation of vasoconstriction pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENSA, NECAB3, and SLC37A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vasoconstriction activity versus ENSA in KIDNEY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ENSA →	+0.900	+0.146	.003	.005	3	3
BONE	NECAB3 →	+1.359	+0.252	<.001	<.001	3	3
BONE	SLC37A1 →	+2.447	+0.320	.005	.003	3	3
BONE	NEK8 →	+1.217	+0.245	.008	.005	3	3
BONE	EMC10 →	+1.336	+0.239	<.001	.001	3	3
LUNG_NSCLC_LUAD	PWWP2B →	+1.941	+0.188	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045906 vs ENSA — KIDNEY

Explore this scatter interactively →