Negative regulation of translational elongation

Across TCGA patient cohorts, RNA activity of the Negative regulation of translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHFL, GPR65, and SLC9A9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of translational elongation activity versus SHFL in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SHFL →	+0.557	+0.082	.002	.002	3	4
UCEC	GPR65 →	+0.559	+0.110	<.001	<.001	3	4
BRCA	SLC9A9 →	+0.643	+0.105	<.001	<.001	3	4
BRCA	PLSCR1 →	+0.927	+0.113	<.001	<.001	3	4
LUAD	EBI3 →	+0.454	+0.438	.002	.006	3	4
LUAD	MS4A1 →	+0.737	+0.501	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045900 vs SHFL — BRCA

Explore this scatter interactively →