Negative regulation of translational elongation

Across TCGA patient cohorts, RNA activity of the Negative regulation of translational elongation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHFL, XAF1, and ANKRD44, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of translational elongation activity versus SHFL in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SHFL →	+0.536	+0.281	<.001	.002	3	6
BRCA	XAF1 →	+0.631	+0.109	<.001	<.001	3	4
BRCA	ANKRD44 →	+0.330	+0.077	<.001	.007	2	5
PDAC	CARMIL2_S1315 →	+1.196	+0.187	<.001	.001	3	3
UCEC	NIBAN1_S646 →	+0.802	+0.155	<.001	<.001	3	3
LSCC	TJP1_S275 →	+1.160	+0.373	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045900 vs SHFL — GBM

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