Negative regulation of translational elongation

Across TCGA cell cohorts, RNA activity of the Negative regulation of translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FYN, SKAP2, and THBS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FYN grouped by Negative regulation of translational elongation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FYN →	+2.890	+0.150	.008	.002	3	5
BREAST	SKAP2 →	+2.038	+0.153	.001	<.001	3	5
STOMACH	THBS3 →	+1.951	+0.183	.009	.003	3	4
OESOPHAGUS	RASA3 →	+1.280	+0.083	.001	<.001	3	4
STOMACH	NQO2 →	-1.267	-0.118	.003	.002	3	4
BREAST	MRPS7 →	-0.846	-0.146	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FYN by Negative regulation of translational elongation activity — STOMACH

Explore this box plot interactively →