Regulation of RNA polymerase II transcription preinitiation complex assembly

Across TCGA cell cohorts, RNA activity of the Regulation of RNA polymerase II transcription preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAICS, ZEB1, and ERCC8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of RNA polymerase II transcription preinitiation complex assembly activity versus PAICS in BLOOD_Leukemia (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PAICS →	+0.617	+0.164	.001	.007	3	6
OVARY	ZEB1 →	+1.820	+0.295	.005	.002	3	6
BLOOD_Leukemia	ERCC8 →	+0.466	+0.157	.006	.007	3	5
BLOOD_Leukemia	CYFIP2 →	+2.040	+0.147	<.001	.001	3	5
BLOOD_Leukemia	PMS1 →	+0.447	+0.151	<.001	<.001	3	5
BLOOD_Leukemia	WDR62 →	+0.909	+0.200	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045898 vs PAICS — BLOOD_Leukemia

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