Positive regulation of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN8, AP1G2, and CDH3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPN8 grouped by Positive regulation of sister chromatid cohesion-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CAPN8 →	+0.116	+0.993	.002	.001	3	5
BLOOD_Leukemia	AP1G2 →	+0.616	+0.989	.006	<.001	3	4
BREAST	CDH3 →	+2.035	+0.523	.002	.002	3	4
SKIN	DDIAS →	-0.608	-0.707	.001	.009	3	3
OVARY	COX7C →	+0.516	+0.892	.005	.006	3	3
CNS	RAB3IP →	+1.333	+1.410	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPN8 by Positive regulation of sister chromatid cohesion activity — SKIN

Explore this box plot interactively →