Positive regulation of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL23, ZNF852, and TAF6L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sister chromatid cohesion activity versus KLHL23 in LUNG_NSCLC_LUSC (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KLHL23 →	+1.524	+0.422	.001	.005	2	7
LUNG_SCLC	ZNF852 →	+0.781	+0.152	.002	.001	3	5
SKIN	TAF6L →	+0.814	+0.269	<.001	.002	3	5
BLOOD_Leukemia	TIMELESS →	+0.581	+0.100	.002	.007	3	5
PANCREAS	SLC26A10 →	-1.401	-0.179	.007	.004	3	5
BREAST	EZH2 →	+0.995	+0.226	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045876 vs KLHL23 — LUNG_NSCLC_LUSC

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