Negative regulation of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of sister chromatid cohesion pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESPL1, NAA10, and GSTM5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ESPL1 grouped by Negative regulation of sister chromatid cohesion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ESPL1 →	-0.429	-0.247	<.001	<.001	3	9
OVARY	NAA10 →	-0.318	-0.139	<.001	.003	3	9
LUNG_NSCLC_LUAD	GSTM5 →	+0.199	+0.154	<.001	<.001	3	4
PANCREAS	HECTD4 →	-0.193	-0.151	.001	.007	3	4
LUNG_NSCLC_LUSC	IFNGR1 →	-0.211	-0.273	.006	.002	3	4
OESOPHAGUS	TRPC4 →	+0.198	+0.201	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ESPL1 by Negative regulation of sister chromatid cohesion activity — BLOOD_Leukemia

Explore this box plot interactively →