Negative regulation of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAA15, LSM12, and PSD4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sister chromatid cohesion activity versus NAA15 in LARGE_INTESTINE (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NAA15 →	+0.651	+0.206	.005	.008	3	7
BLOOD_Myeloma	LSM12 →	+0.495	+0.189	.001	.002	3	6
URINARY_TRACT	PSD4 →	-3.969	-0.545	.001	.006	3	5
PANCREAS	ABCC3 →	-1.632	-0.297	.005	.002	3	5
LARGE_INTESTINE	NPM1 →	+0.731	+0.267	.004	.002	2	6
URINARY_TRACT	PRR15 →	-4.883	-0.542	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045875 vs NAA15 — LARGE_INTESTINE

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