Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

Across TCGA patient cohorts, RNA activity of the Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM10, CENPP, and CENPO, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate activity versus MCM10 in COAD (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MCM10 →	+0.643	+1.013	<.001	<.001	3	6
LSCC	CENPP →	+0.430	+0.245	.007	.008	3	6
COAD	CENPO →	+0.495	+0.867	<.001	<.001	3	5
COAD	NCAPG2 →	+0.603	+0.896	<.001	<.001	3	5
COAD	RFWD3 →	+0.499	+0.607	<.001	.005	3	5
UCEC	RAD54L →	+0.935	+0.473	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045869 vs MCM10 — COAD

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