Negative regulation of proteolysis

Across TCGA cell cohorts, RNA activity of the Negative regulation of proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF2BP2, APOL1, and IMPDH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of proteolysis activity versus IRF2BP2 in SKIN (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IRF2BP2 →	+0.407	+0.198	.004	.001	3	4
BLOOD_Myeloma	APOL1 →	-2.601	-0.242	.001	<.001	3	4
LARGE_INTESTINE	IMPDH1 →	+1.148	+0.396	<.001	<.001	3	4
STOMACH	PHLDB2 →	-3.853	-0.277	.001	.009	3	4
BLOOD_Leukemia	DUSP1 →	-1.562	-0.335	.002	.005	3	3
STOMACH	GPR35 →	+4.050	+0.343	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045861 vs IRF2BP2 — SKIN

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