Positive regulation of protein kinase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GAS7, STAB1, and ARHGAP9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein kinase activity activity versus GAS7 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GAS7 →	+0.419	+0.021	<.001	<.001	3	9
GBM	STAB1 →	+0.626	+0.036	<.001	<.001	3	8
GBM	ARHGAP9 →	+0.505	+0.033	<.001	<.001	3	8
GBM	PLEKHO2 →	+0.379	+0.033	<.001	<.001	3	8
OV	RTN1 →	+0.425	+0.021	.001	<.001	3	7
BRCA	S100B →	+0.749	+0.018	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045860 vs GAS7 — BRCA

Explore this scatter interactively →