Positive regulation of protein kinase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCF4, EIF3J, and TGFBR1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein kinase activity activity versus NCF4 in COAD (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NCF4 →	+1.104	+2.130	.003	<.001	3	1
COAD	EIF3J →	+1.059	+2.035	.005	<.001	3	1
COAD	TGFBR1 →	+0.724	+1.705	.004	.008	3	1
COAD	CHORDC1 →	+1.202	+2.119	.007	<.001	3	1
COAD	TSKS →	+0.278	+2.089	.007	<.001	3	1
COAD	THAP10 →	+0.562	+1.725	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045860 vs NCF4 — COAD

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